轻便小巧低功耗,制造成本仅约34美元(相比于运行这种测试的高于10000美元的实验室机器设备成本)
医护人员在卢旺达测试了这个新配件,检测了疾病预防控制中心收集的96例血液样品电子狗进行了三重免疫检测:同时检测hiv抗体,梅毒螺旋体特异性抗体和针对梅毒的非螺旋体抗体15分钟的测试结果与实验室检测结果比对后证实,电子狗的hiv elisa和快速血浆反应(梅毒筛选实验)的灵敏度达到92~100%,特异性达到79%-100%,与目前临床的算法需求相一致而97%的病人也表态更愿意使用电子狗
a smartphone dongle for diagnosis of infectious diseases at the point of care
信息来源:生物谷
本文系生梅毒的早期症状查询物谷原创编译整理,欢迎转载!转载请注明来源并附原文链接谢谢!
科研人员把达到实验室标准的一个完整免疫检测改造到了这个小小的配件上这种电子狗能复制基于实验室的酶联免疫吸附测定(elisa)所有机械,光学和电子功能,由提供电量电子狗产生的数据会通过智能的标准音频插孔传送到内存
这项研究提示我们,消费类电子产品的进展可以使越来越多的某些基于实验室的诊断走出实验室,只用接入到智能即可这样几乎世界各地的人口都可能更方便的接受诊断这无疑是一个十分令人兴奋的消息(生物谷bioon.com)
图:哥伦比亚大学研发的dongle
abstract
2015年2月6日 讯 /生物谷bioon/ --哥伦比亚大学生物医学工程和卢旺达生物医学中心的研女性梅毒的早期症状究人员联手,研发并成功测试了一个智能电子狗(dongle),只需15分钟就可得到hiv和梅毒诊断这篇文章发表在最新一期的science translational medicine
hiv和梅毒在发展中国家比较常见,而患者能获得的医疗保健往往有限所以科研人员试图突破依赖常规实验室的诊断方法,寻找一种即廉价又便携的设备用于诊断
tassaneewan laksanasopin, tiffany w. guo, samiksha nayak, archana a. sridhara, shi xie, owolabi o. olowookere, paolo cadinu, fanxing meng, nat淋病梅毒传播途径alie h. chee, jiyoon kim, curtis d. chin, elisaphane munyazesa, placidie mugwaneza, alex j. rai, veronicah mugisha, arnold r. castro, david steinmiller, vincent linder, jessica e. justman, sabin nsanzimana and samuel k. sia1
关键词:hiv,梅毒,智能,电子狗
this work demonstrates that a full laboratory-quality immuno梅毒潜伏期assay can be run on a smartphone accessory. this low-cost dongle replicates all mechanical, optical, and electronic functions of a laboratory-based enzyme-linked immunosorbent assay (elisa) without requiring any stored energy; all necessary power is drawn from a smartphone. rwandan health care workers脓疱性梅毒疹 used the dongle to test whole blood obtained via fingerprick from 96 patients enrolling into care at prevention of mother-to-child transmission clinics or voluntary counseling and testing centers. the dongle performed a triplexed immunoassay not currently available in a single test format: hiv antibo梅毒的早期症状男dy, treponemal-specific antibody for syphilis, and nontreponemal antibody for active syphilis infection. in a blinded experiment, health care workers obtained diagnostic results in 15 min from our triplex test that rivaled the gold standard of laboratory-based hiv elisa and rapid plasma reagin (a scree梅毒有哪些传播途径ning test for syphilis), with sensitivity of 92 to 100% and specificity of 79 to 100%, consistent with needs of current clinical algorithms. patient preference for the dongle was 97% compared to laboratory-based tests, with most pointing to the convenience of obtaining quick results with a single fingerprick. this 梅毒的治疗work suggests that coupling microfluidics with recent advances in consumer electronics can make certain laboratory-based diagnostics accessible to almost any population with access to smartphones.
doi： 10.1126 / scitranslmed.aaa0056
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